David Marsden Award 2021
The award was introduced by Dystonia Europe in 2003 and is presented every two years to stimulate research on dystonia, especially by young scientists in Europe.
Professor David Marsden (1938 – 1998) was one of the leading neurologists in Europe and DE wishes to honor the enormous part he played in developing knowledge of and interest in dystonia.
The David Marsden Award 2021 was awarded to Dr. Martin Reich, Julius Maximilian’s University, department of Neurology in Würzburg, Germany for his paper:
Probalistic mapping of the antidystonic effect of Pallidal neurostimulation: a multi-centre imaging study.
Dr. Reich was presented with the award by Dystonia Europe President Adam Kalinowski at the Basal Ganglia Session at the on-line EAN (European Academy of Neurology) Congress on 19 June 2021, and at the digital Dystonia-Days 2021 held on 5 September. Dr Reich expressed his thanks to DE and Ipsen for the award and then presented the work of his research.
About the winner
During Medical School in Kiel, Germany, Dr. Reich got for the first time in touch with movement disorders and the fascinating therapeutic potential of deep brain stimulation. In 2008 he started his doctoral thesis in this field with Jens Volkmann and Guenther Deuschl. After a short stay at King’s College in London and finishing Medical School, he moved to Wuerzburg to start his Residency in Neurology and continuing his scientific efforts in Movement disorders and Brainstimulation. After completing a clinical scientist track he went to Harvard Medical School in Boston for a postdoc stay in the group of Michael Fox. Since 2017 he is leading the visualDBSlab in Wuerzburg focusing on neuroplasticity and network-wide effects of neuromodulation therapies. Additionally he is a senior consultant at the department of Neurology.
About the research
The dystonias are a heterogeneous group of movement disorders sharing the core clinical feature of abnormal involuntary muscle contractions. Pallidal deep brain stimulation by surgical implanted electrodes is an established therapy for severe cases with an average improvement of 50-60 % in dystonia severity. However, outcomes are variable, difficult to predict and clinical studies report up to 25 % of non-responders. Variability in electrode placement and inappropriate stimulation settings may account for a large proportion of this outcome variability. Moreover, dystonia improves delayed, often days to weeks after changing DBS therapy, which complicates programming. Our group has recently identified the location and extent of the volume of tissue activated (VTA) as the most important factor for the therapeutic efficacy of DBS in dystonia. Furthermore, we developed a computer model to predict optimal individual stimulation settings in patients based on the outcome of a big cohort of chronically treated patients by using their pre- and postoperative brain images. In-silico testing has predicted a 16.3 % better mean group improvement with computer-selected programming choices compared to physician-based programming and a drastic reduction of non-responders (from 25 % to 5 %). This study raises hope that in the future computational models may assist lead positioning and programming and provide more consistent outcomes of the surgical therapy in dystonia.
The award is generously sponsored by:
- The David Marsden Award is presented every year from 2022.
- The Award sum is € 10,000 for papers (i.e. manuscripts for original publication – no abstracts) on aetiology, pathogenesis, diagnosis or therapies in dystonia or on the psycho-‐social effects.
- Applicants should be under 45 years of age.
- Submitted papers may have been published within the last two years.
- Unsuccessful applicants may re-‐present their papers in the following year, if fundamental new scientific findings are involved.
- The applicant should be the first author.
- The research must have taken place within Geographical Europe.
- Papers should be submitted by email to the DE Secretariat with a short Curriculum Vitae and a declaration that the paper has not been submitted for any other scientific awards.
- The deadline for submissions is 28 February 2021.
- The evaluation of papers will be carried out by the Dystonia Europe Medical and Scientific Advisory Board and a recommendation made to the DE Managing Board.
- The winner will be invited to make a presentation at the DE annual conference 2021.
Applications for the DMA 2021 will be open from the summer of 2020 through our DMA website
- David Marsden Award 2019 was awarded to Dr. Anne Weissbach
- David Marsden Award 2017 was awarded to Dr. Niccolò Mencacci
- David Marsden Award 2015 was awarded to Dr. Cathérine C S Delnooz
- David Marsden Award 2013 was awarded to Dr. Katja Lohmann
- David Marsden Award 2011 was awarded to Dr David Bradley
- David Marsden Award 2009 was awarded to Dr. Ana Djarmati and Dr. Susanne A. Schneider
- David Marsden Award 2007 was awarded to Dr. Mirta Fiorio
- David Marsden Award 2005 was awarded to Dr. Victor Candia
- David Marsden Award 2003 was awarded to Dr. Mark Edwards