Awards

David Marsden Award 2025

The award was introduced by Dystonia Europe in 2003 and was presented every two years to stimulate research on dystonia, especially by young scientists in Europe. From 2022, the award is presented every year.
Professor David Marsden (1938 – 1998) was one of the leading neurologists in Europe and DE wishes to honor the enormous part he played in developing knowledge of and interest in dystonia.

Our congratulations to Dr. Ahmet Kaymak, from the BioRobotics Institute of Scuola Superiore Sant’Anna in Italy who has been selected as winner of the David Marsden Award 2025 for his paper: Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes

Dr. Ahmet Kaymak

Dr. Ahmet Kaymak

About Dr. Kaymak:

Dr. Ahmet Kaymak was born in Bayburt, Turkey. He is a neuroengineer with a multidisciplinary background spanning computer engineering, biomedical sciences, and human neurology. He recently completed his doctoral research at the BioRobotics Institute of Scuola Superiore Sant’Anna in Italy.

Dr.  Kaymak holds undergraduate degrees in Computer Engineering and Biomedical Engineering from Fatih Sultan Mehmet Vakıf University in Istanbul, Turkey and subsequently pursued a master’s degree in Bionics Engineering, a joint program between Scuola Superiore Sant’Anna and the University of Pisa, with specialization in neuroengineering. Following this, he joined the Computational Neuroengineering Laboratory at the BioRobotics Institute to carry out his doctoral research.

Dr.  Kaymak’s research lies at the intersection of neuropathophysiology, neuroanatomy, and genetics in the context of movement disorders, with a particular focus on dystonia. Through his research, he aims to elucidate how distinct genetic etiologies impact circuit-level neural dynamics within brain regions involved in motor planning and execution, and how these insights can guide the refinement of neuromodulation therapies to improve treatment outcomes for individuals with dystonia.

About the research:

Dystonia is a complex network disorder, and its inherited forms result from pathogenic mutations across a broad range of genes with diverse cellular functions. Genetic dystonia syndromes present highly variable clinical phenotypes, including age of onset, disease progression, symptom distribution, and psychiatric or cognitive features, as well as widely varying responses to deep brain stimulation (DBS) treatment.

In their study, Dr. Kaymak’s team investigated how the genetic background of dystonia shapes neural activity within the globus pallidum (the target brain region for DBS) and whether characterizing this activity helps explain the variability in treatment response observed across different genetic dystonia syndromes. To explore this, they collected intraoperative recordings from a patient cohort during DBS surgeries and analyzed neural activity using a comprehensive set of metrics capturing functional properties of neurons, including firing regularity, bursting patterns, and oscillatory activity.

Using a combination of multiple statistical and machine learning techniques, the team successfully stratified the pallidal neural activity associated with different dystonia-related genes into two principal groups: those exhibiting strong bursting behavior and those characterized by more regular firing patterns. Notably, their neural stratification of dystonia genes closely mirrors findings previously reported in clinical literature. Patients with mutations in genes such as THAP1 and PANK2 exhibited strong tonic/regular firing patterns and have been reported to show poor or inconsistent responses to DBS. In contrast, mutations in genes like GNAL and SGCE presented prominent bursting firing patterns and were associated with more favorable DBS outcomes. These clinical trends were also reflected significantly within their own patient cohort.

DBS is hypothesized to alleviate motor symptoms by disrupting pathologically synchronized neural activity and restoring more physiological patterns within motor circuits. Dr. Kaymak’s team further hypothesized that pathological synchronization in the dystonic globus pallidum is more effectively sustained by neurons exhibiting bursting behavior (brief episodes of intense activity followed by silence) rather than by neurons with regular firing. Consequently, genetic profiles associated with predominantly regular neural activity may lack sufficient abnormal synchronization, potentially making DBS treatment less effective. They proposed that exploring alternative neuromodulation strategies, such as targeting different brain regions or designing tailored stimulation protocols, may yield better treatment outcomes for these profiles.

General Information

  • The David Marsden Award is presented every year.
  • The Award sum is € 10,000 for papers (i.e. manuscripts for original publication – no abstracts) on aetiology, pathogenesis, diagnosis or therapies in dystonia or on the psycho-­‐social effects.
  • Applicants should be under 45 years of age.
  • Submitted papers may have been published within the last two years.
  • Unsuccessful applicants may re-­‐present their papers in the following year, if fundamental new scientific findings are involved.
  • The applicant should be the first author.
  • The research must have taken place within Geographical Europe.

Procedure

  • Papers should be submitted by email to the DE Secretariat with a short Curriculum Vitae and a declaration that the paper has not been submitted for any other scientific awards.
  • The deadline for submissions is 28 February 2026.
  • The evaluation of papers will be carried out by the Dystonia Europe Medical and Scientific Advisory Board and a recommendation made to the DE Managing Board.
  • The winner will be invited to make a presentation at the Basal Ganglia Club Session at the EAN Congress 2024 in Helsinki in Finland.

Applications for the DMA 2026 is open from 1 September 2025 through our DMA website.

Past Awardees